Cellulite is a condition that affects the skin, giving it a dimpled, lumpy appearance. It is most noticeable on the buttocks and thighs and is more common in females. Cellulite is often classified using three grades, with grade 3 being the most severe. The causes of cellulite are not well understood, but hormonal factors and genetics are believed to play a role. Estrogen is thought to be the most important hormone in initiating and aggravating cellulite.